Resume

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

CRISPR–Cas9 editing generates structural defects of the nucleus, micronuclei, and chromosome bridges, initiating a mutational process called chromothripsis.

mitchell-l.-leibowitz

Mechanisms generating cancer genome complexity from a single cell division error

We elucidate a mutational cascade triggered by a single cell division error that rapidly increases genomic complexity, producing chromothripsis alongside breakage-fusion-bridge …

neil-t.-umbreit