Resume

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome editing. However, the events that lead to these …
Stamatis Papathanasiou, Styliani Markoulaki, Logan J. Blaine, Mitchell L. Leibowitz, Cheng-Zhong Zhang, Rudolf Jaenisch, David Pellman
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Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches …
Mitchell L Leibowitz, Stamatis Papathanasiou, Phillip A Doerfler, Logan J Blaine, Lili Sun, Yu Yao, Cheng-Zhong Zhang, Mitchell J Weiss, David Pellman
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Mechanisms generating cancer genome complexity from a single cell division error
The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. …
Neil T Umbreit, Cheng-Zhong Zhang, Luke D Lynch, Logan J Blaine, Anna M Cheng, Richard Tourdot, Lili Sun, Hannah F Almubarak, Kim Judge, Thomas J Mitchell, Alexander Spektor, David Pellman
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