Article-Journal

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

We show that CRISPR-Cas9 genome editing in mouse embryos can cause whole chromosome loss and genomic instability, tracked through the first three divisions of embryonic …

stamatis-papathanasiou

• Oct 1, 2021 • 1 min read

Resume

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

CRISPR–Cas9 editing generates structural defects of the nucleus, micronuclei, and chromosome bridges, initiating a mutational process called chromothripsis.

mitchell-l.-leibowitz

• Apr 1, 2021 • 1 min read

Resume

Mechanisms generating cancer genome complexity from a single cell division error

We elucidate a mutational cascade triggered by a single cell division error that rapidly increases genomic complexity, producing chromothripsis alongside breakage-fusion-bridge …

neil-t.-umbreit

• Apr 1, 2020 • 1 min read

No results found

Article-Journal

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

Mechanisms generating cancer genome complexity from a single cell division error