IGVF Consortium CRISPR Screen Pipeline

Jun 1, 2024 · 1 min read
projects

Co-led construction of an end-to-end Nextflow pipeline for reproducibility analysis of consortium-scale single-cell CRISPR screen datasets, as part of the IGVF consortium CRISPR Focus Group.

See the associated manuscript, A unified end-to-end pipeline for reproducibility analysis of consortium-scale single-cell CRISPR screen datasets (in preparation).

Logan Blaine
Authors
PhD Candidate in Bioinformatics and Integrative Genomics

Logan is a Ph.D. candidate in Biomedical Informatics at Harvard Medical School building probabilistic machine learning systems that reason over large-scale biological data. His work in the Pinello Lab develops Bayesian & deep learning models — spanning representation learning, generative modeling, and causal inference — to turn high-throughput single-cell experiments into testable hypotheses about biological mechanism, with the broader goal of building computational systems that can reason under uncertainty and close the loop with experimental biology.

Outside of lab, he enjoys training for marathons (and the occasional IRONMAN triathlon) and bikepacking around Vermont.